Kumayambiriro kwa chaka cha 2025, ofufuza ochokera ku University of Washington ndi Brigham and Women's Hospital (chipatala chophunzitsira cha Harvard Medical School) adavumbulutsa njira yosayerekezeka yochiritsira matenda a Alzheimer's - kupumaxenonmpweya, womwe sumangoletsa kutupa kwa ubongo ndi kuchepetsa kufooka kwa ubongo, komanso umawonjezera chitetezo cha mitsempha.

Xenonndi chitetezo cha mitsempha

Matenda a Alzheimer's ndi matenda ofala kwambiri omwe amawononga mitsempha mwa anthu, ndipo chifukwa chake chimakhulupirira kuti chikugwirizana ndi kuchulukana kwa mapuloteni a tau ndi beta-amyloid muubongo. Ngakhale kuti pakhala mankhwala omwe amayesa kuchotsa mapuloteni oopsa awa, sanagwire ntchito pochepetsa kupita patsogolo kwa matendawa. Chifukwa chake, chomwe chimayambitsa matendawa kapena chithandizo chake sichikumveka bwino.

Kafukufuku wasonyeza kuti kupumaxenonakhoza kudutsa chotchinga cha magazi ndi ubongo ndikukweza kwambiri momwe mbewa zilili ndi mitundu ya matenda a Alzheimer's m'malo ochitira kafukufuku.Kuyeseraku kunagawidwa m'magulu awiri, gulu limodzi la mbewa linasonyeza kuchuluka kwa mapuloteni a tau ndipo gulu lina linali ndi kuchuluka kwa mapuloteni a beta-amyloid. Zotsatira za kuyesaku zinasonyeza kuti xenon sikuti imangopangitsa mbewa kukhala zogwira ntchito kwambiri, komanso idalimbikitsa chitetezo cha microglia, chomwe ndi chofunikira kwambiri pakuchotsa mapuloteni a tau ndi beta-amyloid.

Kupeza kumeneku ndi kwatsopano kwambiri, kusonyeza kuti mphamvu zoteteza mitsempha zimatha kupangidwa mwa kungopuma mpweya wopanda mpweya. Cholepheretsa chachikulu pa kafukufuku ndi chithandizo cha Alzheimer's ndikuti n'kovuta kwambiri kupanga mankhwala omwe angadutse chotchinga cha magazi ndi ubongo, ndipoxenonakhoza kuchita izi.

Ntchito zina zachipatala za xenon

1. Mankhwala oletsa ululu ndi kuletsa kupweteka: Monga mpweya wabwino kwambiri woletsa ululu,xenonimagwiritsidwa ntchito kwambiri chifukwa cha kupangika kwake mwachangu komanso kuchira, kukhazikika bwino kwa mtima ndi chiopsezo chochepa cha zotsatirapo zoyipa;

2. Mphamvu yoteteza mitsempha: Kuwonjezera pa zotsatira zomwe zingatheke pochiza matenda a Alzheimer omwe atchulidwa pamwambapa, xenon yaphunziridwanso kuti ichepetse kuwonongeka kwa ubongo komwe kumachitika chifukwa cha matenda a hypoxic-ischemic encephalopathy (HIE) a makanda;

3. Kuika ziwalo ndi kuziteteza:Xenoningathandize kuteteza ziwalo zoperekedwa ku kuvulala kwa ischemia-reperfusion, zomwe ndizofunikira kwambiri pakukweza kuchuluka kwa bwino kwa kuikidwa kwa ziwalo zina;

4. Kuzindikira khansa pogwiritsa ntchito radiotherapy: Kafukufuku wina woyambirira wasonyeza kuti xenon ikhoza kuwonjezera mphamvu ya khansa pogwiritsa ntchito radiotherapy, zomwe zimapereka njira yatsopano yochizira khansa;